Ontology highlight
ABSTRACT:
SUBMITTER: Geismann C
PROVIDER: S-EPMC6032098 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Geismann Claudia C Erhart Wiebke W Grohmann Frauke F Schreiber Stefan S Schneider Günter G Schäfer Heiner H Arlt Alexander A
International journal of molecular sciences 20180604 6
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant neoplasms and registers rising death rates in western countries. Due to its late detection in advanced stages, its extremely aggressive nature and the minimal effectiveness of currently available therapies, PDAC is a challenging problem in the clinical field. One characteristic of PDAC is a distinct desmoplasia consisting of fibroblasts, endothelial and immune cells as well as non-cellular components, contributing to the ...[more]