Ontology highlight
ABSTRACT:
SUBMITTER: Dudas J
PROVIDER: S-EPMC6032238 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Dudás József J Dietl Wolfgang W Romani Angela A Reinold Susanne S Glueckert Rudolf R Schrott-Fischer Anneliese A Dejaco Daniel D Johnson Chacko Lejo L Tuertscher Raphaela R Schartinger Volker Hans VH Riechelmann Herbert H
International journal of molecular sciences 20180614 6
Neurotrophins and their receptors might regulate cell survival in head and neck squamous cell carcinoma (HNSCC). mRNA expression of nerve growth factor (NGF) and protein synthesis of high (NTRK1) and low affinity neurotrophin (p75 neurotrophin receptor; NTR) receptors were investigated in normal oral mucosa and in HNSCC. HNSCC cell lines were treated with mitomycin C (MMC) and cell survival was investigated. Normal and malignant epithelial cells expressed NGF mRNA. NTRK1 was upregulated in 80% o ...[more]