Ontology highlight
ABSTRACT:
SUBMITTER: Kuang Y
PROVIDER: S-EPMC6032239 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Kuang Ye Y Han Xiaoyun X Xu Mu M Wang Yue Y Zhao Yuxiang Y Yang Qing Q
International journal of molecular sciences 20180531 6
Chemical injury is partly due to free radical lipid peroxidation, which can induce oxidative stress and produce a large number of reactive oxygen species (ROS). Oxaloacetic acid is an important intermediary in the tricarboxylic acid cycle (TCA cycle) and participates in metabolism and energy production. In our study, we found that oxaloacetate (OA) effectively alleviated liver injury which was induced by hydrogen peroxide (H₂O₂) in vitro and carbon tetrachloride (CCl₄) in vivo. OA scavenged ROS, ...[more]