Ontology highlight
ABSTRACT:
SUBMITTER: Brunner HI
PROVIDER: S-EPMC6032847 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Brunner Hermine I HI Tzaribachev Nikolay N Vega-Cornejo Gabriel G Louw Ingrid I Berman Alberto A Calvo Penadés Inmaculada I Antón Jordi J Ávila-Zapata Francisco F Cuttica Rubén R Horneff Gerd G Foeldvari Ivan I Keltsev Vladimir V Kingsbury Daniel J DJ Viola Diego Oscar DO Joos Rik R Lauwerys Bernard B Paz Gastañaga Maria Eliana ME Rama Maria Elena ME Wouters Carine C Bohnsack John J Breedt Johannes J Fischbach Michel M Lutz Thomas T Minden Kirsten K Miraval Tatiana T Ally Mahmood M T M MMTM Rubio-Pérez Nadina N Solau Gervais Elisabeth E van Zyl Riana R Li Xiaohui X Nys Marleen M Wong Robert R Banerjee Subhashis S Lovell Daniel J DJ Martini Alberto A Ruperto Nicolino N
Arthritis & rheumatology (Hoboken, N.J.) 20180520 7
<h4>Objective</h4>To investigate the pharmacokinetics, effectiveness, and safety of subcutaneous (SC) abatacept treatment over 24 months in patients with polyarticular-course juvenile idiopathic arthritis (JIA).<h4>Methods</h4>In this phase III, open-label, international, multicenter, single-arm study, patients with polyarticular JIA (cohort 1, ages 6-17 years and cohort 2, ages 2-5 years) in whom treatment with ≥1 disease-modifying antirheumatic drug was unsuccessful received weight-tiered SC a ...[more]