Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case-control study.

ABSTRACT:

Introduction

Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The MYCN oncogene is amplified in some neuroblastoma patients and correlated with poor prognosis. However, less is known regarding the relationship between MYCN gene single-nucleotide polymorphisms (SNPs) and neuroblastoma risk.

Patients and methods

To investigate the contribution of MYCN gene polymorphisms to neuroblastoma risk, we performed a 3-center case-control study by genotyping 4 SNPs in the MYCN gene from 429 cases and 884 controls.

Results

The results showed that only rs57961569 G>A was associated with neuroblastoma risk (GA vs GG: adjusted odds ratio =0.76, 95% confidence interval =0.60-0.98, P=0.033), while the other 3 SNPs were not (rs965

SUBMITTER: Zhou H 

PROVIDER: S-EPMC6033082 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature