The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites.
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ABSTRACT:
SUBMITTER: O'Reilly J
PROVIDER: S-EPMC6034155 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites.
O'Reilly Jessica J Pangilinan Faith F Hokamp Karsten K Ueland Per M PM Brosnan John T JT Brosnan Margaret E ME Brody Lawrence C LC Molloy Anne M AM
Molecular genetics and metabolism reports 20180611
The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variation within GCS genes in a sample of young, healthy individuals. Fifty-two variants tagging (r<sup>2</sup> < 0.9) the four GCS genes were tested; one variant, <i>GLDC</i> rs2297442-G, was significantly associated (<i>p</i> = .0007) with decreased glycin ...[more]
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