Ontology highlight
ABSTRACT:
SUBMITTER: Jensen DD
PROVIDER: S-EPMC6034632 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Jensen Dane D DD Lieu TinaMarie T Halls Michelle L ML Veldhuis Nicholas A NA Imlach Wendy L WL Mai Quynh N QN Mai Quynh N QN Poole Daniel P DP Quach Tim T Aurelio Luigi L Conner Joshua J Herenbrink Carmen Klein CK Barlow Nicholas N Simpson Jamie S JS Scanlon Martin J MJ Graham Bimbil B McCluskey Adam A Robinson Phillip J PJ Escriou Virginie V Nassini Romina R Materazzi Serena S Geppetti Pierangelo P Hicks Gareth A GA Christie Macdonald J MJ Porter Christopher J H CJH Canals Meritxell M Bunnett Nigel W NW
Science translational medicine 20170501 392
Typically considered to be cell surface sensors of extracellular signals, heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) control many pathophysiological processes and are the target of 30% of therapeutic drugs. Activated receptors redistribute to endosomes, but researchers have yet to explore whether endosomal receptors generate signals that control complex processes in vivo and are viable therapeutic targets. We report that the substance P (SP) neurokinin 1 receptor (N ...[more]