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Recurrence of tuberculosis among newly diagnosed sputum positive pulmonary tuberculosis patients treated under the Revised National Tuberculosis Control Programme, India: A multi-centric prospective study.


ABSTRACT: INTRODUCTION:There is lack of information on the proportion of new smear-positive pulmonary tuberculosis (PTB) patients treated with a 6-month thrice-weekly regimen under Revised National Tuberculosis Control Programme (RNTCP) who develop recurrent TB after successful treatment outcome. OBJECTIVE:To estimate TB recurrence among newly diagnosed PTB patients who have successfully completed treatment and to document endogenous reactivation or re-infection. Risk factors for unfavourable outcomes to treatment and TB recurrence were determined. METHODOLOGY:Adult (aged ? 18 yrs) new smear positive PTB patients initiated on treatment under RNTCP were enrolled from sites in Tamil Nadu, Karnataka, Delhi, Maharashtra, Madhya Pradesh and Kerala. Those declared "treatment success" at the end of treatment were followed up with 2 sputum examinations each at 3, 6 and 12 months after treatment completion. MIRU-VNTR genotyping was done to identify endogenous re-activation or exogenous re-infection at TB recurrence. TB recurrence was expressed as rate per 100 person-years (with 95% confidence interval [95%CI]). Regression models were used to identify the risk factors for unfavourable response to treatment and TB recurrence. RESULTS:Of the1577 new smear positive PTB patients enrolled, 1565 were analysed. The overall cure rate was 77% (1207/1565) and treatment success was 77% (1210 /1565). The cure rate varied from 65% to 86%. There were 158 of 1210 patients who had TB recurrence after treatment success. The pooled TB recurrence estimate was 10.9% [95%CI: 0.2-21.6] and TB recurrence rate per 100 person-years was 12.7 [95% CI: 0.4-25]. TB recurrence per 100 person-years varied from 5.4 to 30.5. Endogenous reactivation was observed in 56 (93%) of 60 patients for whom genotyping was done. Male gender was associated with TB recurrence. CONCLUSION:A substantial proportion of new smear positive PTB patients successfully treated with 6 -month thrice-weekly regimen have TB recurrence under program settings.

SUBMITTER: Velayutham B 

PROVIDER: S-EPMC6034867 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Recurrence of tuberculosis among newly diagnosed sputum positive pulmonary tuberculosis patients treated under the Revised National Tuberculosis Control Programme, India: A multi-centric prospective study.

Velayutham Banurekha B   Chadha Vineet Kumar VK   Singla Neeta N   Narang Pratibha P   Gangadhar Rao Vikas V   Nair Sanjeev S   Ramalingam Srinivasan S   Narayanan Sivaramakrishnan Gomathi G   Joseph Bency B   Selvaraju Sriram S   Shanmugam Shivakumar S   Narang Rahul R   Pachikkaran Praseeja P   Bhat Jyothi J   Ponnuraja Chinnaiyan C   Bajaj Bhalla Bhoomika B   Shivashankara Bhadravathi Amarnath BA   Sebastian George G   Yadav Rajiv R   Kumar Sharma Ravendra R   Sarin Rohit R   Myneedu Vithal Prasad VP   Singla Rupak R   Khayyam Khalidumer K   Mrithunjayan Sunil Kumar SK   Jayasankar Subramonia Pillai SP   Sanker Praveen P   Viswanathan Krishnaveni K   Viswambharan Rajeevan R   Mathuria Kapil K   Bhalla Manpreet M   Singh Nitu N   Tumane Kondeshvar Balaji KB   Dawale Ajay A   Tiwari Chandra Prakash CP   Bansod Radhelal R   Jayabal Lavanya L   Murali Lakshmi L   Khaparde Sunil D SD   Rao Raghuram R   Jawahar Mohideen S MS   Natrajan Mohan M  

PloS one 20180706 7


<h4>Introduction</h4>There is lack of information on the proportion of new smear-positive pulmonary tuberculosis (PTB) patients treated with a 6-month thrice-weekly regimen under Revised National Tuberculosis Control Programme (RNTCP) who develop recurrent TB after successful treatment outcome.<h4>Objective</h4>To estimate TB recurrence among newly diagnosed PTB patients who have successfully completed treatment and to document endogenous reactivation or re-infection. Risk factors for unfavourab  ...[more]

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