The impact of temporal sampling resolution on parameter inference for biological transport models.

ABSTRACT: Imaging data has become an essential tool to explore key biological questions at various scales, for example the motile behaviour of bacteria or the transport of mRNA, and it has the potential to transform our understanding of important transport mechanisms. Often these imaging studies require us to compare biological species or mutants, and to do this we need to quantitatively characterise their behaviour. Mathematical models offer a quantitative description of a system that enables us to perform this comparison, but to relate mechanistic mathematical models to imaging data, we need to estimate their parameters. In this work we study how collecting data at different temporal resolutions impacts our ability to infer parameters of biological transport models by performing exact inference fo

SUBMITTER: Harrison JU 

PROVIDER: S-EPMC6034909 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature