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Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response.

ABSTRACT: We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gamma-producing T cells with corresponding decrease in interleukin 17A and interleukin 10-producing T cells. Our results suggest that gut microbiome modulation could emerge as a novel immunotherapeutic strategy.

SUBMITTER: Sethi V

PROVIDER: S-EPMC6035070 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response.

Sethi Vrishketan V Kurtom Saba S Tarique Mohammad M Lavania Shweta S Malchiodi Zoe Z Hellmund Leonor L Zhang Li L Sharma Umakant U Giri Bhuwan B Garg Bharti B Ferrantella Anthony A Vickers Selwyn M SM Banerjee Sulagna S Dawra Rajinder R Roy Sabita S Ramakrishnan Sundaram S Saluja Ashok A Dudeja Vikas V

Gastroenterology 20180407 1

We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gam ...[more]

PMID: 29630898

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