Dataset Information

Chromothripsis in acute myeloid leukemia: biological features and impact on survival.

ABSTRACT: Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one or few chromosomes in multiple fragments and consequent random rejoining and repair. This study defines incidence of chromothripsis in 395 newly diagnosed adult acute myeloid leukemia (AML) patients from three institutions, its impact on survival and its genomic background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were performed on all samples. We detected chromothripsis with a custom algorithm in 26/395 patients. Patients harboring chromothripsis had higher age (p?=?0.002), ELN high risk (HR) (p?

SUBMITTER: Fontana MC

PROVIDER: S-EPMC6035145 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Chromothripsis in acute myeloid leukemia: biological features and impact on survival.

Fontana Maria Chiara MC Marconi Giovanni G Feenstra Jelena D Milosevic JDM Fonzi Eugenio E Papayannidis Cristina C Ghelli Luserna di Rorá Andrea A Padella Antonella A Solli Vincenza V Franchini Eugenia E Ottaviani Emanuela E Ferrari Anna A Baldazzi Carmen C Testoni Nicoletta N Iacobucci Ilaria I Soverini Simona S Haferlach Torsten T Guadagnuolo Viviana V Semerad Lukas L Doubek Michael M Steurer Michael M Racil Zdenek Z Paolini Stefania S Manfrini Marco M Cavo Michele M Simonetti Giorgia G Kralovics Robert R Martinelli Giovanni G

Leukemia 20180223 7

Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one or few chromosomes in multiple fragments and consequent random rejoining and repair. This study defines incidence of chromothripsis in 395 newly diagnosed adult acute myeloid leukemia (AML) patients from three institutions, its impact on survival and its genomic background. SNP 6.0 or CytoscanHD Array (Affymetrix<sup>®</sup>) were performed on all samples. We detected chromothripsis with a custom algorith ...[more]

PMID: 29472722

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Project description:Background: Adolescents and young adults (AYA; 15-39 years) with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) experience inferior survival when compared with children. Impact of care at NCI-designated Comprehensive Cancer Centers (CCC) or Children's Oncology Group sites (COG) on survival disparities remains unstudied.Methods: Using the Los Angeles cancer registry, we identified 1,870 ALL or AML patients between 1 and 39 years at diagnosis. Cox regression analyses assessed risk of mortality; younger age + CCC/COG served as the referent group. Logistic regression was used to determine odds of care at CCC/COG, adjusting for variables above.Results: ALL outcome: AYAs at non-CCC/COG experienced inferior survival (15-21 years: HR = 1.9, P = 0.005; 22-29 years: HR = 2.6, P < 0.001; 30-39 years: HR = 3.0, P < 0.001). Outcome at CCC/COG was comparable between children and young AYAs (15-21 years: HR = 1.3, P = 0.3; 22-29 years: HR = 1.2, P = 0.2) but was inferior for 30- to 39-year-olds (HR = 3.4, P < 0.001). AML outcome: AYAs at non-CCC/COG experienced inferior outcome (15-21 years: HR = 1.8, P = 0.02; 22-39 years: HR = 1.4, P = 0.06). Outcome at CCC/COG was comparable between children and 15- to 21-year-olds (HR = 1.3, P = 0.4) but was inferior for 22- to 39-year-olds (HR = 1.7, P = 0.05). Access: 15- to 21-year-olds were less likely to use CCC/COG than children (P < 0.001). In 22- to 39-year-olds, public/uninsured (ALL: P = 0.004; AML<0.001), African American/Hispanics (ALL: P = 0.03), and 30- to 39-year-olds (ALL: P = 0.03) were less likely to use CCC/COG.Conclusions: Poor survival in AYAs with ALL and AML is mitigated by care at CCC/COG. Barriers to CCC/COG care include public/uninsured, and African American/Hispanic race/ethnicity.Impact: Care at CCC/COG explains, in part, inferior outcomes in AYAs with ALL and AML. Key sociodemographic factors serve as barriers to care at specialized centers. Cancer Epidemiol Biomarkers Prev; 26(3); 312-20. ©2017 AACR.

Dataset Information

Chromothripsis in acute myeloid leukemia: biological features and impact on survival.

Publications

Chromothripsis in acute myeloid leukemia: biological features and impact on survival.

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