Dataset Information

Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma.

ABSTRACT:

Background

Recent clinical studies have suggested that programmed death ligand 1 (PD-L1) expression in a tumour could be a potential biomarker for PD-L1/PD-1 blockade therapies.

Methods

To better characterise PD-L1 expression in hepatocellular carcinoma (HCC), we analysed its expression patterns in 453 HCC patients by double staining for CD68 and PD-L1 using the Tyramide Signal Amplification Systems combined with immunohistochemistry. We also investigated its correlation with clinical features, prognosis and immune status.

Results

The results showed that PD-L1 expression on tumour cells (TCs) was negatively associated with patients' overall survival (OS; P?=?0.001) and relapse-free survival (RFS; P?=?0.006); however, PD-L1 expression on macrophages (M?s) was positively correlated with OS (P?=?0.017). Multivariate analysis revealed that PD-L1 expression on TCs and M?s were both independent prognostic factors for OS (hazard ratio (HR)?=?1.168, P?=?0.004 for TC-PD-L1; HR?=?0.708, P?=?0.003 for M?-PD-L1). Further studies showed that M?-PD-L1⁺ tumours exhibited an activated immune microenvironment, with high levels of CD8⁺ T-cell infiltration and immune-related gene expression.

Conclusion

Our study provided a novel methodology to evaluate PD-L1 expression in the tumour microenvironment, which might help to select patients who would benefit from anti-PD-1/PD-L1 immunotherapies.

SUBMITTER: Liu CQ

PROVIDER: S-EPMC6035200 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma.

Liu Chao-Qun CQ Xu Jing J Zhou Zhong-Guo ZG Jin Li-Lian LL Yu Xing-Juan XJ Xiao Gang G Lin Jie J Zhuang Shi-Mei SM Zhang Yao-Jun YJ Zheng Limin L

British journal of cancer 20180620 1

<h4>Background</h4>Recent clinical studies have suggested that programmed death ligand 1 (PD-L1) expression in a tumour could be a potential biomarker for PD-L1/PD-1 blockade therapies.<h4>Methods</h4>To better characterise PD-L1 expression in hepatocellular carcinoma (HCC), we analysed its expression patterns in 453 HCC patients by double staining for CD68 and PD-L1 using the Tyramide Signal Amplification Systems combined with immunohistochemistry. We also investigated its correlation with clin ...[more]

PMID: 29921949

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Dataset Information

Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma.

Background

Methods

Results

Conclusion

Publications

Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma.

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