Glycan recognition in globally dominant human rotaviruses.
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ABSTRACT:
SUBMITTER: Hu L
PROVIDER: S-EPMC6035239 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Glycan recognition in globally dominant human rotaviruses.
Hu Liya L Sankaran Banumathi B Laucirica Daniel R DR Patil Ketki K Salmen Wilhelm W Ferreon Allan Chris M ACM Tsoi Phoebe S PS Lasanajak Yi Y Smith David F DF Ramani Sasirekha S Atmar Robert L RL Estes Mary K MK Ferreon Josephine C JC Prasad B V Venkataram BVV
Nature communications 20180706 1
Rotaviruses (RVs) cause life-threatening diarrhea in infants and children worldwide. Recent biochemical and epidemiological studies underscore the importance of histo-blood group antigens (HBGA) as both cell attachment and susceptibility factors for the globally dominant P[4], P[6], and P[8] genotypes of human RVs. How these genotypes interact with HBGA is not known. Here, our crystal structures of P[4] and a neonate-specific P[6] VP8*s alone and in complex with H-type I HBGA reveal a unique gly ...[more]
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