Dataset Information

Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Inflammation is a common feature of both peripheral arterial disease (PAD) and periodontitis. Some studies have evaluated the association between PAD and periodontitis. However, there is still no specialized meta-analysis that has quantitatively assessed the strength of the association. Thus, we conducted this meta-analysis to critically assess the strength of the association between PAD and periodontitis.

Methods

PubMed, Embase, and the Cochrane Library were searched for observational studies of the association between periodontitis and PAD in February 2018. Risk ratios (RRs) and their 95% confidence intervals (CIs) from included studies were pooled to evaluate the strength of the association between periodontitis and PAD. Weighted mean differences (WMDs) and their 95% CIs were pooled to compare the difference in periodontal-related parameters between PAD and non-PAD patients.

Results

Seven studies including a total of 4307 participants were included in the meta-analysis. The pooled analysis showed that there was a significant difference in the risk of periodontitis between PAD patients and non-PAD participants (RR?=?1.70, 95% CI?=?1.25-2.29, P?=?0.01). There was also a significant difference in number of missing teeth between PAD patients and non-PAD participants (WMD?=?3.75, 95% CI?=?1.31-6.19, P?=?0.003). No significant difference was found in clinical attachment loss between PAD patients and non-PAD participants (WMD?=?-?0.05, 95% CI?=?-?0.03-0.19, P?=?0.686).

Conclusion

In conclusion, the results of this meta-analysis revealed a significant relationship between periodontitis and PAD. Moreover, our study indicated that PAD patients had more missing teeth than control subjects did. Further high-quality and well-designed studies with specific inclusion and exclusion criteria are required to strengthen the conclusions of this study.

SUBMITTER: Yang S

PROVIDER: S-EPMC6035462 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis.

Yang Shuo S Zhao Li Sheng LS Cai Chuan C Shi Quan Q Wen Ning N Xu Juan J

BMC cardiovascular disorders 20180706 1

<h4>Background</h4>Inflammation is a common feature of both peripheral arterial disease (PAD) and periodontitis. Some studies have evaluated the association between PAD and periodontitis. However, there is still no specialized meta-analysis that has quantitatively assessed the strength of the association. Thus, we conducted this meta-analysis to critically assess the strength of the association between PAD and periodontitis.<h4>Methods</h4>PubMed, Embase, and the Cochrane Library were searched f ...[more]

PMID: 29980169

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Project description:BackgroundEvidence from previous studies reporting on the relationship between tea consumption and its preventive effect on coronary artery disease (CAD) has conflicting outcomes. With the accumulation of new clinical evidence, we conducted this meta-analysis to assess tea consumption and CAD risk.MethodsWe searched PubMed, EMBASE, Cochrane Library, and Medline databases for published observational studies from their inception to May 2022. A random-effects model was used to calculate risk ratios with 95% confidence intervals. We also conducted linear and non-linear dose-response meta-analyses to analyze the association. We regarded that one cup equals 237 mL. Subgroup analyses and univariate meta-regression were conducted to explore the source of heterogeneity.ResultsA total of 35 studies, including 24 on green tea and 11 on black tea consumption, were included in this meta-analysis. An inverse association for the risk of CAD was observed for black tea (RR: 0.85; 95% CI: 0.76, 0.96) and green tea (RR: 0.93; 95% CI: 0.88, 0.99). The dose-response meta-analysis showed that drinking less than four cups of black tea daily may effectively prevent CAD, while more than 4-6 cups/d will promote disease risk. Furthermore, the dose-response relationship between green tea consumption and the prevention of CAD showed that the risk of CAD gradually decreased as green tea consumption increased. We also demonstrated that the more cups of green tea consumed, the lower the risk of CAD. In the subgroup analysis by continent, a significant negative correlation between CAD risk and green tea consumption was observed in the Asian population (RR: 0.92; 95% CI: 0.85, 0.99) but not in the western population [North America (RR: 0.97; 95% CI: 0.92, 1.03), Europe/Oceana (RR: 0.91; 95% CI: 0.78, 1.07)].ConclusionsHigher green tea consumption was associated with reduced CAD risk, but drinking more than 4-6 cups of black tea per day may increase the risk. This study offers new insight into the relationship between tea consumption and its preventive effect on CAD. However, further large prospective cohort studies are needed to validate these findings.Systematic review registrationThe protocol of this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) system (CRD42022348069).

Dataset Information

Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis.

Background

Methods

Results

Conclusion

Publications

Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis.

Similar Datasets

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