High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma.
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ABSTRACT:
SUBMITTER: Niu H
PROVIDER: S-EPMC6035719 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma.
Niu Haitao H Li Feng F Wang Qingshui Q Ye Zhoujie Z Chen Qi Q Lin Yao Y
PeerJ 20180704
Matrix metallopeptidase 9 (MMP9) was found to be associated with tumor aggressiveness. In this study, we focused on the correlation between MMP9 expression and clear cell renal carcinoma (ccRCC). Through the Gene Expression Omnibus (GEO) database, the Cancer Genome Atlas (TCGA) database and immunohistochemical (IHC) staining, we observed that compared with adjacent normal renal tissues, in ccRCC tissues the mRNA and protein levels of MMP9 were enhanced, and the mRNA levels of GTP-binding protein ...[more]
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