Posttranslational Modifications of RAS Proteins.
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ABSTRACT:
SUBMITTER: Ahearn I
PROVIDER: S-EPMC6035883 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Posttranslational Modifications of RAS Proteins.
Ahearn Ian I Zhou Mo M Philips Mark R MR
Cold Spring Harbor perspectives in medicine 20181101 11
The three human <i>RAS</i> genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review. ...[more]
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