Ontology highlight
ABSTRACT:
SUBMITTER: King LA
PROVIDER: S-EPMC6036112 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
King Lisa A LA Lameris Roeland R de Gruijl Tanja D TD van der Vliet Hans J HJ
Frontiers in immunology 20180702
CD1d-restricted invariant natural killer T (iNKT) cells are considered an attractive target for cancer immunotherapy. Upon their activation by glycolipid antigen and/or cytokines, iNKT cells can induce direct lysis of tumor cells but can also induce an antitumor immune response <i>via</i> their rapid production of proinflammatory cytokines that trigger the cytotoxic machinery of other components of the innate and adaptive immune system. Here, we provide an overview of various therapeutic approac ...[more]