Ontology highlight
ABSTRACT:
SUBMITTER: Downes NL
PROVIDER: S-EPMC6036226 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Downes Nicholas L NL Laham-Karam Nihay N Kaikkonen Minna U MU Ylä-Herttuala Seppo S
Molecular therapy : the journal of the American Society of Gene Therapy 20180509 7
Effective vascular regeneration could provide therapeutic benefit for multiple pathologies, especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia inducible factors (HIFs) mediate the cellular transcriptional response to hypoxia and regulate multiple processes that are required for angiogenesis to ultimately restore perfusion and oxygen supply. In endothelial cells, both HIF1α and HIF2α are known to contribute to this role; however, the extent and individual r ...[more]