Unknown

Dataset Information

0

PRWHMDA: Human Microbe-Disease Association Prediction by Random Walk on the Heterogeneous Network with PSO.


ABSTRACT: Microorganisms resided in human body play a vital role in metabolism, immune defense, nutrition absorption, cancer control and protection against pathogen colonization. The changes of microbial communities can cause human diseases. Based on the known microbe-disease association, we presented a novel computational model employing Random Walking with Restart optimized by Particle Swarm Optimization (PSO) on the heterogeneous interlinked network of Human Microbe-Disease Associations (PRWHMDA) (see Figure 1). Based on the known human microbe-disease associations, we constructed the heterogeneous interlinked network with Cosine similarity. The extended random walk with restart (RWR) method was derived to get the potential microbe-disease associations. PSO was utilized to get the optimal parameters of RWR. To evaluate the prediction effectiveness, we performed leave one out cross validation (LOOCV) and 5-fold cross validation (CV), which got the AUC (The area under ROC curve) of 0.915 (LOOCV) and the average AUCs of 0.8875 ± 0.0046 (5-fold CV). Moreover, we carried out three case studies of asthma, inflammatory bowel disease (IBD) and type 1 diabetes (T1D) for the further evaluation. The result showed that 10, 10 and 9 of top-10 predicted microbes were verified by previously published experimental results, respectively. It is anticipated that PRWHMDA can be effective to identify the disease-related microbes and maybe helpful to disclose the relationship between microorganisms and their human host.

SUBMITTER: Wu C 

PROVIDER: S-EPMC6036753 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

PRWHMDA: Human Microbe-Disease Association Prediction by Random Walk on the Heterogeneous Network with PSO.

Wu Chuanyan C   Gao Rui R   Zhang Daoliang D   Han Shiyun S   Zhang Yusen Y  

International journal of biological sciences 20180522 8


Microorganisms resided in human body play a vital role in metabolism, immune defense, nutrition absorption, cancer control and protection against pathogen colonization. The changes of microbial communities can cause human diseases. Based on the known microbe-disease association, we presented a novel computational model employing Random Walking with Restart optimized by Particle Swarm Optimization (PSO) on the heterogeneous interlinked network of Human Microbe-Disease Associations (PRWHMDA) (see  ...[more]

Similar Datasets

| S-EPMC6635699 | biostudies-literature
| S-EPMC6967737 | biostudies-literature
| S-EPMC5589230 | biostudies-literature
| S-EPMC8384471 | biostudies-literature
| S-EPMC6832386 | biostudies-literature
| S-EPMC4416812 | biostudies-literature
| S-EPMC6385311 | biostudies-literature
| S-EPMC8729064 | biostudies-literature
| S-EPMC5295400 | biostudies-literature
| S-EPMC5622075 | biostudies-literature