Ontology highlight
ABSTRACT:
SUBMITTER: Bekris LM
PROVIDER: S-EPMC6036902 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Bekris L M LM Khrestian M M Dyne E E Shao Y Y Pillai J A JA Rao S M SM Bemiller S M SM Lamb B B Fernandez H H HH Leverenz J B JB
Journal of neuroimmunology 20180320
Alzheimer's disease (AD) has been genetically and pathologically associated with neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor involved in innate immunity. TREM2 rare protein coding genetic variants have been linked to AD. A soluble TREM2 (sTREM2) cleavage product is elevated in AD. It is unclear whether there is a relationship between elevated sTREM2 and markers of inflammation. The hypothesis of this investigation was that central and peri ...[more]