Ontology highlight
ABSTRACT:
SUBMITTER: Ganesan AP
PROVIDER: S-EPMC6036910 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Ganesan Anusha-Preethi AP Clarke James J Wood Oliver O Garrido-Martin Eva M EM Chee Serena J SJ Mellows Toby T Samaniego-Castruita Daniela D Singh Divya D Seumois Grégory G Alzetani Aiman A Woo Edwin E Friedmann Peter S PS King Emma V EV Thomas Gareth J GJ Sanchez-Elsner Tilman T Vijayanand Pandurangan P Ottensmeier Christian H CH
Nature immunology 20170619 8
Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; however, clinical responses to the immunotherapeutic agents currently available vary considerably, and the molecular basis of this is unclear. We performed transcriptomic profiling of tumor-infiltrating CTLs from treatment-naive patients with lung cancer to define the molecular features associated with the robustness of anti-tumor immune responses. We observed considerable heterogeneity in the exp ...[more]