Ontology highlight
ABSTRACT:
SUBMITTER: Cheng TD
PROVIDER: S-EPMC6037104 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cheng Ting-Yuan David TD Darke Amy K AK Redman Mary W MW Zirpoli Gary R GR Davis Warren W Payne Ondracek Rochelle R Bshara Wiam W Omilian Angela R AR Kratzke Robert R Reid Mary E ME Molina Julian R JR Kolesar Jill M JM Chen Yuhchyau Y MacRae Robert M RM Moon James J Mack Philip P Gandara David R DR Kelly Karen K Santella Regina M RM Albain Kathy S KS Ambrosone Christine B CB
Journal of the National Cancer Institute 20180701 7
<h4>Background</h4>To what extent steroid hormones contribute to lung cancer in male and female never smokers and smokers is unclear. We examined expression of hormone receptors in lung tumors by sex and smoking.<h4>Methods</h4>Patients with primary non-small cell lung cancer were recruited into an Intergroup study in the United States and Canada, led by SWOG (S0424). Tumors from 813 cases (450 women and 363 men) were assayed using immunohistochemistry for estrogen receptor (ER)-α, ER-β, progest ...[more]