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Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction.


ABSTRACT: We have developed a practical synthesis of unique nucleoside derivatives via TiCl(4) promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation.

SUBMITTER: Ghosh AK 

PROVIDER: S-EPMC6037177 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction.

Ghosh Arun K AK   Kass Jorden J  

Chemical communications (Cambridge, England) 20100125 8


We have developed a practical synthesis of unique nucleoside derivatives via TiCl(4) promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation. ...[more]

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