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Genetically-Predicted Adult Height and Alzheimer's Disease.


ABSTRACT: Observational studies have linked increased adult height with better cognitive performance and reduced risk of Alzheimer's disease (AD). It is unclear whether the associations are due to shared biological processes that influence height and AD or due to confounding by early life exposures or environmental factors.To use a genetic approach to investigate the association between adult height and AD.We selected 682 single nucleotide polymorphisms (SNPs) associated with height at genome-wide significance (p?

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC6037293 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Genetically-Predicted Adult Height and Alzheimer's Disease.

Larsson Susanna C SC   Traylor Matthew M   Burgess Stephen S   Markus Hugh S HS  

Journal of Alzheimer's disease : JAD 20170101 2


<h4>Background</h4>Observational studies have linked increased adult height with better cognitive performance and reduced risk of Alzheimer's disease (AD). It is unclear whether the associations are due to shared biological processes that influence height and AD or due to confounding by early life exposures or environmental factors.<h4>Objective</h4>To use a genetic approach to investigate the association between adult height and AD.<h4>Methods</h4>We selected 682 single nucleotide polymorphisms  ...[more]

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