Dataset Information

The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis.

ABSTRACT:

Objectives

Rheumatoid arthritis (RA) patients often take non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids as supportive drugs. In this study, we investigated the prevalence of endoscopic gastric damage and their prescribed medications under an actual clinical condition.

Methods

We collected the data of 1704 RA patients who underwent upper gastrointestinal fiberscopy. Gastric mucosal erosion and ulcer were classified using modified LANZA score. We analyzed these data with a multiple regression analysis.

Results

The prevalence of endoscopic gastric mucosal damage in these RA patients was 16.7% (285 cases). A multiple regression analysis indicated that prednisolone (PSL), NSAIDs and proton pump inhibitors (PPIs) were independent risk factors associated with the modified LANZA score. PSL and NSAIDs were positively correlated with the score, while the administration of PPIs was inversely correlated with the score. The modified LANZA score in RA patients treated with both PSL and NSAIDs was significantly higher than that in those treated with PSL alone (no NSAIDs use).

Conclusions

Our findings suggest that PSL and NSAIDs were exacerbating factors for gastric mucosal damage, while PPIs usage was a protective factor. And, the combined usage of corticosteroids and NSAIDs may induce the development of gastric ulcers.

SUBMITTER: Tsujimoto S

PROVIDER: S-EPMC6037345 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis.

Tsujimoto Saki S Mokuda Sho S Matoba Kenichiro K Yamada Akihiro A Jouyama Kazuo K Murata Yosuke Y Ozaki Yoshio Y Ito Tomoki T Nomura Shosaku S Okuda Yasuaki Y

PloS one 20180709 7

<h4>Objectives</h4>Rheumatoid arthritis (RA) patients often take non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids as supportive drugs. In this study, we investigated the prevalence of endoscopic gastric damage and their prescribed medications under an actual clinical condition.<h4>Methods</h4>We collected the data of 1704 RA patients who underwent upper gastrointestinal fiberscopy. Gastric mucosal erosion and ulcer were classified using modified LANZA score. We analyzed these d ...[more]

PMID: 29985937

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Dataset Information

The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis.

Objectives

Methods

Results

Conclusions

Publications

The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis.

Similar Datasets

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