Dataset Information
Cost-effectiveness analysis of routine 13-valent pneumococcal conjugate vaccinations in Chinese infants.
Ontology highlight
ABSTRACT: Background
This study aimed to evaluate the cost-effectiveness of the 13-valent pneumococcal conjugate vaccine (PCV-13) compared to a no vaccination strategy in Chinese infants.Methods
A Markov process model was developed to examine the outcomes of PCV-13 against a no vaccination strategy using data and assumptions adapted for relevance to China. Outcomes over a lifetime horizon are presented. One-way and probabilistic sensitivity analyses were performed to determine the uncertainty.Results
Compared to no vaccination, a PCV-13 vaccination program would provide a gain of 0.009 additional quality-adjusted life years (QALYs) per subject. From the health care and societal perspectives, the incremental costs per QALY were $20,709 and 18,483, respectively. When herd effect was included, the cost effectiveness of the PCV-13 vaccination strategy was notably improved. The lower price of PCV-13 will improve the cost-effectiveness.Conclusions
The PCV-13 vaccination is likely to be cost-effective at the current Chinese prices and ceiling threshold ($8,382).
SUBMITTER: Zhou H
PROVIDER: S-EPMC6037447 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Cost-effectiveness analysis of routine 13-valent pneumococcal conjugate vaccinations in Chinese infants.
Human vaccines & immunotherapeutics 20180409 6
<h4>Background</h4>This study aimed to evaluate the cost-effectiveness of the 13-valent pneumococcal conjugate vaccine (PCV-13) compared to a no vaccination strategy in Chinese infants.<h4>Methods</h4>A Markov process model was developed to examine the outcomes of PCV-13 against a no vaccination strategy using data and assumptions adapted for relevance to China. Outcomes over a lifetime horizon are presented. One-way and probabilistic sensitivity analyses were performed to determine the uncertai ...[more]