Diagnostic and prognostic values of blood microRNA-Let7A for osteosarcoma.

ABSTRACT:

Objective

In view of the poor prognosis and difficulties in the diagnosis of osteosarcoma, and the functionality of microRNA-Let7A in different types of human cancers, our study aimed to explore the diagnostic and prognostic values of microRNA-Let7A for osteosarcoma.

Methods

A total of 39 patients with osteosarcoma and 19 normal healthy people were included in this study. All patients received surgical resection, and tumor tissues as well as pericarcinomatous tissues were collected during surgical operation. Venous blood (2 ml) was extracted from each participant. Expression of microRNA-Let7A in tumor tissues and pericarcinomatous tissues, and expression of E2F2 and microRNA-Let7A in blood of each participant was detected by qRT-PCR. ROC analysis was performed to evaluate th

SUBMITTER: Hua J 

PROVIDER: S-EPMC6037640 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature