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Gut microbiota associations with common diseases and prescription medications in a population-based cohort.


ABSTRACT: The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.

SUBMITTER: Jackson MA 

PROVIDER: S-EPMC6037668 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Gut microbiota associations with common diseases and prescription medications in a population-based cohort.

Jackson Matthew A MA   Verdi Serena S   Maxan Maria-Emanuela ME   Shin Cheol Min CM   Zierer Jonas J   Bowyer Ruth C E RCE   Martin Tiphaine T   Williams Frances M K FMK   Menni Cristina C   Bell Jordana T JT   Spector Tim D TD   Steves Claire J CJ  

Nature communications 20180709 1


The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseas  ...[more]

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