Ontology highlight
ABSTRACT:
SUBMITTER: Torralba D
PROVIDER: S-EPMC6037695 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Torralba Daniel D Baixauli Francesc F Villarroya-Beltri Carolina C Fernández-Delgado Irene I Latorre-Pellicer Ana A Acín-Pérez Rebeca R Martín-Cófreces Noa B NB Jaso-Tamame Ángel Luis ÁL Iborra Salvador S Jorge Inmaculada I González-Aseguinolaza Gloria G Garaude Johan J Vicente-Manzanares Miguel M Enríquez José Antonio JA Mittelbrunn María M Sánchez-Madrid Francisco F
Nature communications 20180709 1
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic ...[more]