Ontology highlight
ABSTRACT:
SUBMITTER: Painter HJ
PROVIDER: S-EPMC6037754 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Painter Heather J HJ Chung Neo Christopher NC Sebastian Aswathy A Albert Istvan I Storey John D JD Llinás Manuel M
Nature communications 20180709 1
Genome-wide analysis of transcription in the malaria parasite Plasmodium falciparum has revealed robust variation in steady-state mRNA abundance throughout the 48-h intraerythrocytic developmental cycle (IDC), suggesting that this process is highly dynamic and tightly regulated. Here, we utilize rapid 4-thiouracil (4-TU) incorporation via pyrimidine salvage to specifically label, capture, and quantify newly-synthesized RNA transcripts at every hour throughout the IDC. This high-resolution global ...[more]