Ontology highlight
ABSTRACT:
SUBMITTER: Surmeier DJ
PROVIDER: S-EPMC6037988 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Surmeier D James DJ Halliday Glenda M GM Simuni Tanya T
Experimental neurology 20170802 Pt B
Parkinson's disease is characterized by progressively distributed Lewy pathology and neurodegeneration. The motor symptoms of clinical Parkinson's disease (cPD) are unequivocally linked to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Several features of these neurons appear to make them selectively vulnerable to factors thought to cause cPD, like aging, genetic mutations and environmental toxins. Among these features, Ca<sup>2+</sup> entry through Cav1 ch ...[more]