Ontology highlight
ABSTRACT:
SUBMITTER: Ni T
PROVIDER: S-EPMC6038146 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ni Ting T Li Xiao-Yan XY Lu Na N An Teng T Liu Zhi-Ping ZP Fu Rong R Lv Wen-Cong WC Zhang Yi-Wei YW Xu Xiao-Jun XJ Grant Rowe R R Lin Yong-Shun YS Scherer Amanda A Feinberg Tamar T Zheng Xiao-Qi XQ Chen Bao-An BA Liu X Shirley XS Guo Qing-Long QL Wu Zhao-Qiu ZQ Weiss Stephen J SJ
Nature cell biology 20161017 11
The zinc-finger transcription factor Snail1 is inappropriately expressed in breast cancer and associated with poor prognosis. While interrogating human databases, we uncovered marked decreases in relapse-free survival of breast cancer patients expressing high Snail1 levels in tandem with wild-type, but not mutant, p53. Using a Snail1 conditional knockout model of mouse breast cancer that maintains wild-type p53, we find that Snail1 plays an essential role in tumour progression by controlling the ...[more]