The TGF?-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs.
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ABSTRACT:
SUBMITTER: Pellatt AJ
PROVIDER: S-EPMC6038278 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs.
Pellatt Andrew J AJ Mullany Lila E LE Herrick Jennifer S JS Sakoda Lori C LC Wolff Roger K RK Samowitz Wade S WS Slattery Martha L ML
Journal of translational medicine 20180709 1
<h4>Background</h4>The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been seen as key events in CRC progression.<h4>Methods</h4>In this study we comprehensively evaluate differential gene expression (RNASeq) of 81 genes in the TGFβ-signaling pathway and evaluate how dysregulated genes are associated with miRNA expression (Agilent Human miRNA Micr ...[more]
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