Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats.

ABSTRACT:

Background

In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the 'small for size' liver syndrome. The study investigates possible causes of the delayed onset of hepatocyte proliferation after subtotal hepatectomy (80% liver resection) in rats.

Results

The data indicate that the growth inhibition correlates with delayed upregulation of the Tnf gene expression and low content of the corresponding Tnf? protein within the residual hepatic tissue. Considering the involvement of Tnf/Tnf?, the observed growth inhibition may be related to particular properties of liver macrophages - the resident Kupffer cells with CD68⁺CX1CR3^-CD11b^- phenotype.

Conclusions

The delayed onset of hepatocyte proliferation correlates with low levels of Tnf? in the residual hepatic tissue. The observed growth inhibition possibly reflects specific composition of macrophage population of the liver. It is entirely composed of embryonically-derived Kupffer cells, which express the 'proregeneratory' M2 macrophage-specific marker CD206 in the course of regeneration.

SUBMITTER: Elchaninov AV 

PROVIDER: S-EPMC6038314 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature