Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero.
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ABSTRACT:
SUBMITTER: Pepe GJ
PROVIDER: S-EPMC6038696 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero.
Pepe Gerald J GJ Maniu Adina A Aberdeen Graham G Lynch Terrie J TJ Kim Soon Ok SO Nadler Jerry J Albrecht Eugene D ED
Endocrine 20161021 3
We recently demonstrated that offspring delivered to baboons deprived of estrogen during the second half of gestation exhibited insulin resistance prior to onset of puberty. Because gonadal hormones have a profound effect on insulin action and secretion in adults, we determined whether insulin resistance is retained after initiation of gonadal secretion of testosterone and estradiol. Glucose tolerance tests were performed in postpubertal baboon offspring of untreated and letrozole-treated animal ...[more]
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