Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis.

ABSTRACT: Introduction: The fundamental role of the cerebellum in higher cognitive processing has recently been highlighted. However, inconsistent findings exist in schizophrenia with respect to the exact nature of cerebellar structural abnormalities and their associations with cognitive and clinical features. Materials and Methods: We undertook a detailed investigation of cerebellar lobular volumes in 40 patients with first-episode psychosis (FEP) and 40 healthy controls (HCs) using the spatially unbiased atlas template of the cerebellum (SUIT). We examined the functional significance of cerebellar structural abnormalities in relation to cognitive and clinical outcomes in patients. Results: We found that left cerebellar lobules VI and X volumes were lower in FEP patients, compa

SUBMITTER: Kim T 

PROVIDER: S-EPMC6038730 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature