Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates.
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ABSTRACT:
SUBMITTER: Moretto L
PROVIDER: S-EPMC6038798 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates.
Moretto Luisa L Vance Steven S Heames Brennan B Broadhurst R William RW
Chemical communications (Cambridge, England) 20171005 83
Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5'-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation. ...[more]
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