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Simulating optical coherence tomography for observing nerve activity: A finite difference time domain bi-dimensional model.

ABSTRACT: We present a finite difference time domain (FDTD) model for computation of A line scans in time domain optical coherence tomography (OCT). The OCT output signal is created using two different simulations for the reference and sample arms, with a successive computation of the interference signal with external software. In this paper we present the model applied to two different samples: a glass rod filled with water-sucrose solution at different concentrations and a peripheral nerve. This work aims to understand to what extent time domain OCT can be used for non-invasive, direct optical monitoring of peripheral nerve activity.

SUBMITTER: Troiani F

PROVIDER: S-EPMC6039043 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Simulating optical coherence tomography for observing nerve activity: A finite difference time domain bi-dimensional model.

Troiani Francesca F Nikolic Konstantin K Constandinou Timothy G TG

PloS one 20180710 7

We present a finite difference time domain (FDTD) model for computation of A line scans in time domain optical coherence tomography (OCT). The OCT output signal is created using two different simulations for the reference and sample arms, with a successive computation of the interference signal with external software. In this paper we present the model applied to two different samples: a glass rod filled with water-sucrose solution at different concentrations and a peripheral nerve. This work ai ...[more]

PMID: 29990346

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