Ontology highlight
ABSTRACT:
SUBMITTER: Mirbaha H
PROVIDER: S-EPMC6039173 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Mirbaha Hilda H Chen Dailu D Morazova Olga A OA Ruff Kiersten M KM Sharma Apurwa M AM Liu Xiaohua X Goodarzi Mohammad M Pappu Rohit V RV Colby David W DW Mirzaei Hamid H Joachimiak Lukasz A LA Diamond Marc I MI
eLife 20180710
Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer-inert (M<sub>i</sub>) and seed-competent (M<sub>s</sub>). Recombinant M<sub>s</sub> triggered intracellular tau aggregation, induced tau fibrillization in vitro, and self-assembled. M<sub>s</sub> from Alzheimer's disease also seeded aggregation and self-assembled in vitro ...[more]