Increased Soluble CD137 Levels and CD4+ T-Cell-Associated Expression of CD137 in Acute Atherothrombotic Stroke.
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ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC6039206 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Increased Soluble CD137 Levels and CD4+ T-Cell-Associated Expression of CD137 in Acute Atherothrombotic Stroke.
He Yang Y Ao Dong-Hui DH Li Xiao-Qing XQ Zhong Shan-Shan SS A Rong R Wang Yang-Yang YY Xiang Ya-Juan YJ Xu Bao-Lei BL Yang Ting-Ting TT Gao Xu-Guang XG Liu Guang-Zhi GZ
Clinical and translational science 20180426 4
As a proinflammatory cytokine, CD137 (4-1BB, TNFRSF9) is present in membrane-bound and soluble forms. Increased expression of CD137 was recently found in T cells in human atherosclerotic plaques. However, the exact role of CD137 in ischemic stroke is not clear. In this study we analyzed the protein levels of soluble CD137 (sCD137) and the expression of CD137 on CD4+ T cells in the peripheral blood of patients with acute atherothrombotic stroke by using the cytometry beads array (CBA) and flow cy ...[more]
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