Association between RAD51 135 G/C polymorphism and risk of 3 common gynecological cancers: A meta-analysis.

ABSTRACT: Available data concerning the association between RAD51?135G/C (rs1801320) polymorphism and the risk of 3 common gynecological cancers still could not reach a consensus. Thus, we conducted a meta-analysis to explore the relationship.Several electronic databases and bibliographies of relevant articles were screened to identify the studies up to July 2017. Then a meta-analysis was performed to evaluate the connection between 3 common gynecological tumors' susceptibility and RAD51?135G/C polymorphism in different inheritance models. Simultaneously, we did subgroup analysis and sensitivity analysis if necessary.A total of 11 articles including 14 studies involving 4097 cases and 5890 controls were included in this meta-analysis. Overall, RAD51?135G/C polymorphism increased the risk of 3 common gynecological tumors. The subgroup analysis stratified by cancer types- endometrial carcinoma (EC) and ovarian cancer (OC)-showed that RAD51?135G/C polymorphism increased the risk of EC: allele model (C vs G: odds ratio [OR]?=?4.32, 95% confidence interval [CI]?=?2.63-7.10, P?

SUBMITTER: Zeng X 

PROVIDER: S-EPMC6039596 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature