Ontology highlight
ABSTRACT:
SUBMITTER: Wohlever ML
PROVIDER: S-EPMC6040593 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wohlever Matthew L ML Mateja Agnieszka A McGilvray Philip T PT Day Kasey J KJ Keenan Robert J RJ
Molecular cell 20170714 2
Mislocalized tail-anchored (TA) proteins of the outer mitochondrial membrane are cleared by a newly identified quality control pathway involving the conserved eukaryotic protein Msp1 (ATAD1 in humans). Msp1 is a transmembrane AAA-ATPase, but its role in TA protein clearance is not known. Here, using purified components reconstituted into proteoliposomes, we show that Msp1 is both necessary and sufficient to drive the ATP-dependent extraction of TA proteins from the membrane. A crystal structure ...[more]