Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila.

ABSTRACT: Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report a molecular pathway regulating the immune response and involving the communication between embryonic and larval hematopoietic waves in Drosophila. Down-regulating the transcription factor Gcm specific to embryonic hematopoiesis enhances the larval phenotypes induced by over-expressing the pro-inflammatory Jak/Stat pathway or by wasp infestation. Gcm works by modulating the transduction of the Upd cytokines to the site of larval hematopoiesis and hence the response to ch

SUBMITTER: Bazzi W 

PROVIDER: S-EPMC6040882 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature