Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering.
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ABSTRACT:
SUBMITTER: Rimmerman D
PROVIDER: S-EPMC6041135 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering.
Rimmerman Dolev D Leshchev Denis D Hsu Darren J DJ Hong Jiyun J Abraham Baxter B Kosheleva Irina I Henning Robert R Chen Lin X LX
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20180701 7
The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien-protein association. ...[more]
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