Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC6041257 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Lu Jinqiu J Liu Liansheng L Zheng Mingjie M Li Xiaoling X Wu Ailing A Wu Qingzhe Q Liao Cheng C Zou Jian J Song Hai H
Oncogene 20180417 28
Hedgehog (Hh) pathway plays a pivotal role in diverse aspects of development and postnatal physiology. Perturbation of Hh signaling and activation of GLI1 (glioma-associated oncogene 1), a dedicated transcription factor for Hh pathway, are highly associated with several cancers, such as medulloblastoma and basal cell carcinoma. Dynamic and precise control of GLI1 activity is thus important to ensure proper homeostasis and tumorigenesis. Here we show that MEKK2 (MAP3K2) and MEKK3 (MAP3K3) inhibit ...[more]