Ontology highlight
ABSTRACT: Significance
This study shows that H2S can effective targeting inhibits MGAT5 activity, and demonstrates promising antitumor efficacy. These findings gain mechanistic insights into the anti-cancer capacity of H2S and may provide useful information for the clinical explorations of H2S in cancer treatment.
SUBMITTER: Wang R
PROVIDER: S-EPMC6041565 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Translational oncology 20180531 4
Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H<sub>2</sub>S), has not been widely recognized. It intrigued broad interest to explore the clinical benefits of cancer therapy, with the current understanding of molecular mechanisms of H<sub>2</sub>S which remains very ...[more]