Staphylococcus aureus targets the purine salvage pathway to kill phagocytes.
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ABSTRACT:
SUBMITTER: Winstel V
PROVIDER: S-EPMC6042115 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
<i>Staphylococcus aureus</i> targets the purine salvage pathway to kill phagocytes.
Winstel Volker V Missiakas Dominique D Schneewind Olaf O
Proceedings of the National Academy of Sciences of the United States of America 20180611 26
<i>Staphylococcus aureus</i> colonizes large segments of the human population and causes invasive infections due to its ability to escape phagocytic clearance. During infection, staphylococcal nuclease and adenosine synthase A convert neutrophil extracellular traps to deoxyadenosine (dAdo), which kills phagocytes. The mechanism whereby staphylococcal dAdo intoxicates phagocytes is not known. Here we used CRISPR-Cas9 mutagenesis to show that phagocyte intoxication involves uptake of dAdo via the ...[more]
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