Dataset Information

Risk of pleural empyema in patients with schizophrenia: a nationwide propensity-matched cohort study in Taiwan.

ABSTRACT:

Objective

Thoracic infection and pneumonia are prevalent in patients with schizophrenia; however, it is unclear whether patients with schizophrenia are at an increased risk of developing pleural empyema.

Design

A retrospective cohort study with propensity-matched cohorts with and without schizophrenia.

Setting

Using the National Health Insurance Research Database of Taiwan.

Participants

We identified 55?888 patients with schizophrenia newly diagnosed in 2000-2011 and same number of individuals without schizophrenia as the comparison cohort, frequency matched by propensity scores estimated using age, sex, occupation, income, urbanisation, year of diagnosis and comorbidities.

Primary outcome measures

We assessed incident pleural empyema by the end of 2011 and used the Cox proportional hazards model to calculate the schizophrenia cohort to comparison cohort HR of pleural empyema.

Results

The overall incidence of pleural empyema was 2.44-fold greater in the schizophrenia cohort than in the comparison cohort (4.39vs1.80 per 10?000 person-years), with an adjusted HR of 2.87(95% CI 2.14 to 3.84). Stratified analyses by age, sex, occupation, income, urbanisation and comorbidity revealed significant hazards for pleural empyema associated with schizophrenia in all subgroups.

Conclusions

Patients with schizophrenia are at an increased risk of developing pleural empyema and require greater attention and appropriate support.

SUBMITTER: Shen TC

PROVIDER: S-EPMC6042618 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Risk of pleural empyema in patients with schizophrenia: a nationwide propensity-matched cohort study in Taiwan.

Shen Te-Chun TC Chen Chia-Hung CH Huang Yu-Jhen YJ Lin Cheng-Li CL Chang Ting-Chang TC Tu Chih-Yen CY Hsia Te-Chun TC Shih Chuen-Ming CM Hsu Wu-Huei WH Sung Fung-Chang FC

BMJ open 20180706 7

<h4>Objective</h4>Thoracic infection and pneumonia are prevalent in patients with schizophrenia; however, it is unclear whether patients with schizophrenia are at an increased risk of developing pleural empyema.<h4>Design</h4>A retrospective cohort study with propensity-matched cohorts with and without schizophrenia.<h4>Setting</h4>Using the National Health Insurance Research Database of Taiwan.<h4>Participants</h4>We identified 55 888 patients with schizophrenia newly diagnosed in 2000-2011 and ...[more]

PMID: 29982211

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Project description:BackgroundLiver cancer is among the top five most common cancers globally. Lipid-lowering drugs such as statins can lower the risk of liver cancer, but may also cause liver damage. LipoCol Forte capsules (LFC), a red yeast rice product, have demonstrated significant antihypercholesterolemic effects and a good safety profile in clinical studies.AimTo evaluate whether LFC lowers the risk of liver cancer in adults in this propensity score-matched, nationwide, population-based cohort study.MethodsWe used data from Taiwan's National Health Insurance Research Database, which includes electronic medical records for up to 99.99% of Taiwan's population. LFC users and LFC non-users were matched 1:1 by propensity scores between January 2010 and December 2017. All had follow-up data for at least 1 year. Statistical analyses compared demographic distributions including sex, age, comorbidities, and prescribed medications. Cox regression analyses estimated adjusted hazard ratios (aHRs) after adjusting for potential confounders.ResultsWe enrolled 33231 LFC users and 33231 non-LFC users (controls). No significant differences between the study cohorts were identified regarding comorbidities and medications [standardized mean difference (SMD) < 0.05]. At follow-up, the overall incidence of liver cancer was significantly lower in the LFC cohort compared with controls [aHR 0.91; 95% confidence interval (CI): 0.86-0.95; P < 0.001]. The risk of liver cancer was significantly reduced in both females (aHR 0.87; 95%CI: 0.8-0.94; P < 0.001) and males (aHR 0.93; 95%CI: 0.87-0.98; P < 0.01) in the LFC cohort compared with their counterparts in the non-LFC cohort. The antitumor protective effects applied to patients with comorbidities (including hypertension, ischemic stroke, diabetes mellitus, hyperlipidemia, hepatitis B infection and hepatitis C infection). Those using LFC for more than 84 drug days had a 0.64-fold lower risk of liver cancer compared with controls (P < 0.001). Compared with controls, the risk of developing liver cancer in the LFC cohort progressively decreased over time; the lowest incidence of liver cancer occurred in LFC users followed-up for more than 6 years (27.44 vs 31.49 per 1,000 person-years; aHR 0.75; 95%CI: 0.68-0.82; P < 0.001).ConclusionThis retrospective cohort study indicates that LFC has a significantly protective effect on lowering the risk of liver cancer, in a dose-dependent and time-dependent manner.

Dataset Information

Risk of pleural empyema in patients with schizophrenia: a nationwide propensity-matched cohort study in Taiwan.

Objective

Design

Setting

Participants

Primary outcome measures

Results

Conclusions

Publications

Risk of pleural empyema in patients with schizophrenia: a nationwide propensity-matched cohort study in Taiwan.

Similar Datasets

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