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Higher breast cancer prevalence associated with higher socioeconomic status in the South Korean population; Has it resulted from overdiagnosis?

ABSTRACT: Recently, breast cancer prevalence has increased in South Korea. In this study, we investigated the correlation between breast cancer prevalence and socioeconomic status. This study enrolled 27,331 people who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) IV-VI (2007-2015). In addition, we obtained data from the Korean Statistical Information Service (KSIS) on the breast cancer age-standardized incidence rate (AIR), the age-standardized mortality rate (AMR), the number of women screened, and the number of newly diagnosed patients. The KHANES data showed that breast cancer prevalence was significantly associated with educational level (odds ratio [OR], 2.02; 95% confidence interval [CI], 1.08-3.77 for 10-12 vs. ? 6 years of education, and OR, 2.36; 95% CI, 1.10-5.06 for ? 13 vs. ? 6 years of education). However, there was no significant association of breast cancer prevalence with monthly household income. In a separate analysis of the AIR, AMR, and number of women screened for breast cancer, the AIR increased with the number of women screened, whereas the AMR did not. Furthermore, the number of newly diagnosed patients in all age groups increased over time. The present results demonstrate that the recently increased breast cancer prevalence documented in South Korea may be attributable to earlier detection rather than to a real increase in prevalence, and that breast cancer may be overdiagnosed.

SUBMITTER: Choi SW

PROVIDER: S-EPMC6042748 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Higher breast cancer prevalence associated with higher socioeconomic status in the South Korean population; Has it resulted from overdiagnosis?

Choi Seong-Woo SW Ryu So-Yeon SY Han Mi-Ah MA Park Jong J

PloS one 20180712 7

Recently, breast cancer prevalence has increased in South Korea. In this study, we investigated the correlation between breast cancer prevalence and socioeconomic status. This study enrolled 27,331 people who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) IV-VI (2007-2015). In addition, we obtained data from the Korean Statistical Information Service (KSIS) on the breast cancer age-standardized incidence rate (AIR), the age-standardized mortality rate (AMR) ...[more]

PMID: 30001431

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Project description:BackgroundDiabetes leads to severe complications and imposes health and financial burdens on the society. However, currently existing domestic public health studies of diabetes in South Korea mainly focus on prevalence, and data on the nationwide burden of diabetes in South Korea are lacking. The study aimed to estimate the prevalence and economic burden of diabetes imposed on the South Korean society.MethodsA prevalence-based cost-of-illness study was conducted using the Korean national claims database. Adult diabetic patients were defined as those aged ≥20 years with claim records containing diagnostic codes for diabetes (E10-E14) during at least two outpatient visits or one hospitalization. Direct costs included medical costs for the diagnosis and treatment of diabetes and transportation costs. Indirect costs included productivity loss costs due to morbidity and premature death and caregivers' costs. Subgroup analyses were conducted according to the type of diabetes, age (< 65 vs. ≥65), diabetes medication, experience of hospitalization, and presence of diabetic complications or related comorbidities.ResultsA total of 4,472,133 patients were diagnosed with diabetes in Korea in 2017. The average annual prevalence of diabetes was estimated at 10.7%. The diabetes-related economic burden was USD 18,293 million, with an average per capita cost of USD 4090 in 2019. Medical costs accounted for the biggest portion of the total cost (69.5%), followed by productivity loss costs (17.9%), caregivers' costs (10.2%), and transportation costs (2.4%). According to subgroup analyses, type 2 diabetes, presence of diabetic complications or related comorbidities, diabetes medication, and hospitalization represented the biggest portion of the economic burden for diabetes. As the number of complications increased from one to three or more, the per capita cost increased from USD 3991 to USD 11,965. In inpatient settings, the per capita cost was ~ 10.8 times higher than that of outpatient settings.ConclusionsSouth Korea has a slightly high prevalence and economic burden of diabetes. These findings highlight the need for effective strategies to manage diabetic patients and suggest that policy makers allocate more health care resources to diabetes. This is the first study on this topic, conducted using a nationally representative claims database in South Korea.

Project description:IntroductionEvidence from low-income and middle-income countries suggests that migration status has an impact on health. However, little is known about the effect that migration status has on morbidity in sub-Saharan Africa. The aim of this study is to investigate the association between migration status and hypertension and diabetes and to assess whether the association was modified by demographic and socioeconomic characteristics.MethodsA Quality ofLife survey conducted in 2015 collected data on migration status and morbidity from a sample of 28 007 adults in 508 administrative wards in Gauteng province (GP). Migration status was divided into three groups: non-migrant if born in Gauteng province, internal migrant if born in other South African provinces, and external migrant if born outside of South Africa. Diabetes and hypertension were defined based on self-reported clinical diagnosis. We applied a recently developed original, stepwise-multilevel logistic regression of discriminatory accuracy to investigate the association between migration status and hypertension and diabetes. Potential effect modification by age, sex, race, socioeconomic status (SES) and ward-level deprivation on the association between migration status and morbidities was tested.ResultsMigrants have lower prevalence of diabetes and hypertension. In multilevel models, migrants had lower odds of reporting hypertension than internal migrants (OR=0.86; 95% CI 0.78 to 0.95) and external migrant (OR=0.60; 95% CI 0.49 to 0.75). Being a migrant was also associated with lower diabetes prevalence than being an internal migrant (OR=0.84; 95% CI 0.75 to 0.94) and external migrant (OR=0.53; 95% CI 0.41 to 0.68). Age, race and SES were significant effect modifiers of the association between migration status and morbidities. There was also substantial residual between-ward variance in hypertension and diabetes with median OR of 1.61 and 1.24, respectively.ConclusionsMigration status is associated with prevalence of two non-communicable conditions. The association was modified by age, race and SES. Ward-level effects also explain differences in association.

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Higher breast cancer prevalence associated with higher socioeconomic status in the South Korean population; Has it resulted from overdiagnosis?

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Higher breast cancer prevalence associated with higher socioeconomic status in the South Korean population; Has it resulted from overdiagnosis?

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