Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC6043408 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Yu Yu Y Suryo Rahmanto Yohan Y Lee Meng-Horng MH Wu Pei-Hsun PH Phillip Jude M JM Huang Chuan-Hsiang CH Vitolo Michele I MI Gaillard Stephanie S Martin Stuart S SS Wirtz Denis D Shih Ie-Ming IM Wang Tian-Li TL
Oncogene 20180411 28
Cell motility and invasiveness are prerequisites for dissemination, and largely account for cancer mortality. We have identified an actionable kinase, spleen tyrosine kinase (SYK), which is keenly tightly associated with tumor progression in ovarian cancer. Here, we report that active recombinant SYK directly phosphorylates cortactin and cofilin, which are critically involved in assembly and dynamics of actin filament through phosphorylation signaling. Enhancing SYK activity by inducing expressi ...[more]